Park, Jianfang Liu, E. Yoko Furuya, Elaine L. We extracted K pneumoniae infection data including carbapenem susceptibility and anatomical sites, compared clinical characteristics between CRKP and carbapenem-susceptible K pneumoniae infections, and determined CRKP infection proportions in total K pneumoniae infections in HAI and COI to identify statistically significant trends from to using the Cochran-Armitage trend test. Carbapenem-resistant K pneumoniae contributed Efforts to reduce and prevent CRKP infections in both hospital and community settings were successful and warrant continuation.
Since imipenem became the first carbapenem available inthere have been no "How is crkp transmitted sexual disease" classes of antibiotics targeting drug-resistant Gram-negative bacteria [ 23 ].
Carbapenem-resistant Enterobacteriaceae represent 1 of the 3 urgent antibiotic resistance threats ranked by the Centers for Disease Control and Prevention [CDC] the other 2 are Clostridium difficile and drug-resistant Neisseria gonorrhoeae [http: The most common mechanism for carbapenem resistance in CRE is production of carbapenemases [ 56 ].
Carbapenemases are commonly expressed from mobile genetic elements such as plasmids or transposons, which frequently contain multiple drug-resistant genes and have the potential for widespread transmission to other bacteria via horizontal gene transfer [ 67 ]. Knowledge of temporal trends of CRKP in NYC hospitals is critical because 1 information of temporal trends would inform decisions for antimicrobial stewardship and infection control policymaking and 2 temporal trends of CRKP in NYC hospitals would likely predict temporal trends in various other locations.
We also investigated annual CRKP proportions trends by anatomical sites respiratory, urinary tract, bloodstream, and surgical site and clinical characteristics of CRKP infections. The 3 hospitals share a clinical data warehouse that integrates data from over 20 clinical electronic sources [ 21 ]. The data included the following: As part of an National Institutes of Health-funded project 5R01NRwhose methods were described in Apte et al [ 21 ], a team of clinicians and researchers developed electronic algorithms to define BSI, urinary tract infection UTIpneumonia PNUsurgical site infection SSIthe causative organisms, and antibiotic susceptibility.
We defined COI as an infection that occurred before or How is crkp transmitted sexual disease the 3rd hospital day without being admitted from another healthcare setting and without history of admission to one of the study hospitals within the previous 30 days, and we defined HAI as an infection that occurred after the 3rd hospital day or occurred in persons who were admitted from another healthcare setting or admitted to one of the study hospitals within the previous 30 days.
We categorized the laboratory reports of imipenem- or meropenem-susceptible as carbapenem-susceptible, and we categorized reports of imipenem- or meropenem-resistant or -intermediate as carbapenem-resistant. When there was a discrepant report on susceptibility test for imipenem and meropenem imipenem was susceptible but meropenem was resistant, or vice versawe categorized it
How is crkp transmitted sexual disease resistant.
Each patient was eligible only once.
If K pneumoniae was isolated from multiple anatomical sites either through 1 hospitalization or multiple hospitalizations, only the first infection was counted. Overall, CRKP proportions combined the above 4 sites.