I… am not a big fan of either show. But in the end that only means that each film or song has to meet a very specific set of Tiny toons hookup acme acres style enjoyable qualities for me to like them, and even then, only the very best make it on my favorites list.
I cannot say the same for Tiny Toons and Animaniacs. The variety of circumstances and opportunities for humor are greater in Animaniacs than in Tiny Toons. Thus they and their films were locked away, never to seen again; until they escaped in the modern day.
So Animaniacs is a world where cartoon characters are created when they are drawn, and yet they exist among human beings with their own sense of self, their own minds, and personalities. Tiny Toonson the other hand, works on the principle that the main characters, Buster and Babs are anthropomorphized animals that talk and act like human beings, but are otherwise naturally born into families like anyone else.
They also go to school at ACME Looniversity, where I can only assume then that the original Looney Tunes are also naturally born into the world and have simply decided to become comedians in certain types of Hollywood productions. And of course they are now serving their fellow up-and-coming actors as their acting coaches.
The characters themselves even dabble in an animated short film competition at the Looniversity. Now because of this difference in world structure, the dynamic of each show is also drastically different.
In Tiny Toonsthe episodes normally surround the antics of our main adolescent heroes as they deal with school life, life around Acme Acres, or the occasional exploratory adventure outside of town.